A pre-screen approach for MSI from digitized H&E slides

Context

Microsatellite instability (MSI) is a genomic biomarker that plays an important role in the treatment of colorectal tumours (CRC) patients. MSI is predictive of response to immunotherapy across all solid tumors.

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Methods

We developed MSIntuit, an AI based pre-screening tool for MSI detection of CRC from H&E WSI, and performed the first successful blind validation confirming its robustness for clinical applications.

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Results

MSIntuit CRC reaches sensitivity comparable to gold standard methods (92-95%) while ruling out almost half of the MSS patients.

MSIntuit CRC is an interpretable model - it highlights the parts of the slide image used to make its predictions.

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Impact

With a sensitivity of ~95%, MSIntuit CRC can help rule out 40% of CRC patients from reflex screening with standard MMR/MSI testing techniques.

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Learn more about MSIntuit CRC