Case Study
Spatial tumor mapping
Bispecific ADC design, validated in Owkin's wet lab
K Pro
Agentic AI
MOSAIC
Antibody-Drug Conjugate
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OKN3201, potential first-in-class bispecific ADC for solid tumors
Solid tumors are hard to hit with ADCs - antigens are heterogeneous and rarely tumor-specific. K Pro's ADC tools optimized the design of a bispecific ADC for sharpened tumor targeting.
What K Pro did
Spatial tumor mapping: K Pro & MOSAIC
Lead ADC antigen identified
Target pairing: ADC Tool
Second ADC antigen selected for optimized internalization
In vitro validation: wet lab
Bispecific outperformed both monospecific ADCs
Impact
Faster ADC discovery
In-silico triage replaces costly lab cycles
Earlier de-risking
Weak candidates dropped before wet-lab testing
Stronger biological grounding
Spatial and multi-omic context improves target quality
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